abstract：AIMS:p73, a homologue of p53, is known as a negative regulator of tumour progression. However, delta Np73, an isoform of p73 lacking the NH2-terminal transactivation domain plays an oncogenic role by interfering with the activity of p53 and TA (full-length transactivating isoforms) p73. In this study, we investigated t...

journal_title：Pathology

authors： Ito Y,Uramoto H,Funa K,Yoshida H,Jikuzono T,Asahi S,Higashiyama T,Tomoda C,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Kuma K,Miyauchi A

更新日期：2006-06-01 00:00:00

abstract：AIMS:Mixed type liposarcomas are rare. Here, we analysed the characteristics of an unusual case of mixed type liposarcoma, which consisted of a well-differentiated liposarcoma (WDL) and a pleomorphic liposarcoma (PL), with a special emphasis on molecular alterations. METHODS:Microscopic and immunohistochemical approac...

journal_title：Pathology

authors： Kim JI,Choi KU,Lee IS,Moon TY,Lee CH,Kim HW,Kim JY,Park DY,Sol MY

更新日期：2006-04-01 00:00:00

abstract：AIMS:We aimed to evaluate the effects of caffeic acid phenethyl ester (CAPE) on lithium (Li)-induced lung toxicity. METHODS:Twenty-two adult male Wistar albino rats weighing between 280 and 300 g were used. The rats were randomly divided into three groups: control, Li and Li+CAPE groups. Li and CAPE were co-administer...

journal_title：Pathology

authors： Sahin O,Sulak O,Yavuz Y,Uz E,Eren I,Ramazan Yilmaz H,Malas MA,Altuntas I,Songur A

更新日期：2006-02-01 00:00:00

abstract：AIMS:Pancreatic endocrine tumours (PET) containing ductules are an uncommon histological variant. Considerable conjecture surrounds the origin and histogenesis of the ductules. Opinions range from the ductules being an inherent part of the tumour, to others who feel they are merely entrapped. A study of 21 cases of thi...

journal_title：Pathology

authors： Chetty R,Serra S,Asa SL,Volkan Adsay N

更新日期：2006-02-01 00:00:00

abstract：:This review will focus on the molecular biology of lymphoproliferative disorders with emphasis on lymphomas. The spectrum of known recurrent gene rearrangements found in lymphomas will be outlined and their relevance to diagnosis and subclassification of disease will be discussed. Finally, a survey of the current tren...

journal_title：Pathology

authors： Catalano A,Iland H

更新日期：2005-12-01 00:00:00

abstract：AIM:Lignocaine, a topical anaesthetic agent, is generally used in variable concentrations usually between 2% and 4% on the vocal cords prior to flexible bronchoscopy and bronchoalveolar lavage (BAL) procedures. The aim of this study was to investigate whether 2% or 1% lignocaine significantly inhibits the growth of org...

journal_title：Pathology

authors： Chandan SS,Faoagali J,Wainwright CE

更新日期：2005-08-01 00:00:00

abstract：AIM:To demonstrate that Flinders Island spotted fever (FISF), a spotted fever group rickettsial infection caused by Rickettsia honei, is found not only on Flinders Island (Bass Strait), Tasmania, but elsewhere in south-east Australia. METHODS:Cases of FISF were identified by rickettsial serology, culture and the detec...

journal_title：Pathology

authors： Unsworth NB,Stenos J,McGregor AR,Dyer JR,Graves SR

更新日期：2005-06-01 00:00:00

abstract：AIMS:To investigate KAI1 and survivin expression in infiltrating ductal carcinomas, and to evaluate the relationship between clinicopathological factors and KAI1 and survivin expression levels in breast cancers. METHODS AND RESULTS:KAI and survivin expression levels were measured in 62 patients, using immunohistochemi...

journal_title：Pathology

authors： Son BH,Choi JS,Lee JH

更新日期：2005-04-01 00:00:00

abstract：AIMS:Predicting the clinical behaviour of gastrointestinal stromal tumours (GISTs) is difficult and criteria delineating benign from malignant cases are not firmly established. The aims of this study were to define the clinicopathological and molecular features of 66 GISTs, and to determine whether any specific paramet...

journal_title：Pathology

authors： Koay MH,Goh YW,Iacopetta B,Grieu F,Segal A,Sterrett GF,Platten M,Spagnolo DV

更新日期：2005-02-01 00:00:00

abstract：:In 2004, the diagnosis of established human immunodeficiency virus (HIV) infection can be made with close to 100% assurity. The extraordinarily engineered performances of HIV-screening assays are unprecedented. The well-established confirmatory tests performed by well-versed laboratories using criteria that are well u...

journal_title：Pathology

authors： Dax EM,Arnott A

更新日期：2004-12-01 00:00:00

abstract：AIMS:We have identified in malignant melanoma an angio-tumoural complex in which tumour cells occupy a pericytic location along the endothelium of microvessels without evidence of intravasation. This pericytic angiotropism of melanoma cells, without any sign of intravasation, suggests that melanoma cells may migrate al...

journal_title：Pathology

authors： Barnhill RL,Lugassy C

更新日期：2004-10-01 00:00:00

abstract：:Review of problematic melanocytic consultation cases has enabled identification of the most common variants of benign melanocytic proliferations which can be confused with melanoma. Apart from Spitz naevus, the most common in this group of lesions are pigmented spindle cell naevus and atypical dermal nodule. Potential...

journal_title：Pathology

authors： Cook MG

更新日期：2004-10-01 00:00:00

abstract：AIMS:To examine the impact of microwave (MW) tissue processing on turnaround times (TATs) in a routine diagnostic laboratory. METHODS:A retrospective review of TATs for tissue processing (specimen receipt to completion of H&E-stained section) and pathologists' report generation (receipt of stained section to validatio...

journal_title：Pathology

authors： Leong AS,Price D

更新日期：2004-08-01 00:00:00

abstract：AIMS:Twenty-six cases of granulomatous mastitis were examined to determine the common histological and clinical features and the possible association with micro-organisms. METHODS:A retrospective review of the clinical and histological features of these cases was undertaken, including granuloma, inflammatory cell infi...

journal_title：Pathology

authors： Tse GM,Poon CS,Ramachandram K,Ma TK,Pang LM,Law BK,Chu WC,Tang AP,Cheung HS

更新日期：2004-06-01 00:00:00

abstract：AIMS:The roles of tumour suppressor genes: adenomatous polyposis coli (APC) and E-cadherin (CDH1) were investigated in clear cell renal cell carcinoma. METHODS:Forty-five human clear cell renal cell carcinomas were tested for APC gene instability by polymerase chain reaction/loss of heterozygosity using the restrictio...

journal_title：Pathology

authors： Pećina-SLaus N,Gall-TroSelj K,SLaus M,Radić K,NikuSeva-Martić T,Pavelić K

更新日期：2004-04-01 00:00:00

abstract：AIMS:An important consideration in the design of a tumour vaccine is the ability of tumour-specific cytotoxic T lymphocytes (CTL) to recognise unmanipulated tumour cells in vivo. To determine whether B-CLL might use an escape strategy, the current studies compared B-CLL and normal B cell MHC class I expression. METHOD...

journal_title：Pathology

authors： Juffs H,Fowler N,Saal R,Grimmett K,Beasley S,O'Sullivan B,Frazer I,Gill D,Thomas R

更新日期：2004-02-01 00:00:00

abstract：:Oral cancer is a serious public health problem, with over 200,000 new cases reported annually worldwide, two-thirds of which occur in developing countries. The overall mortality rate for intra-oral cancer remains high at approximately 50%, even with modern medical services, probably due to the advanced stage of the di...

journal_title：Pathology

authors： Walker DM,Boey G,McDonald LA

更新日期：2003-10-01 00:00:00

abstract：AIM:Clostridium difficile is the major pathogen associated with nosocomial diarrhoea. We evaluated the performances of a commercially available toxin A enzyme immunoassay (EIA; Clearview C. difficile Toxin A Test), culture and tissue culture cytotoxin assay in the diagnosis of C. difficile-associated diarrhoea. METHOD...

journal_title：Pathology

authors： Anderson TL,McGregor A

更新日期：2003-06-01 00:00:00

abstract：AIMS:To demonstrate the correlation between morphological and proliferation parameters with the biological behaviour of adrenocortical tumours (ACTs) in different age groups. METHODS:Seventy-six cases of ACT were evaluated comparing tumours of children (< or =15 years, n=24) and adults (>15 years, n=52) regarding morp...

journal_title：Pathology

authors： Sredni ST,Alves VA,Latorre Mdo R,Zerbini MC

更新日期：2003-04-01 00:00:00

abstract：AIMS:To assess the production of a liver-specific protein, albumin, and of a master transcriptional factor, hepatocyte nuclear factor (HNF)-4alpha, in hepatoid adenocarcinoma tissue. METHODS:Standard and quantitative RT-PCR, using five cases of hepatoid and three cases of non-hepatoid gastric adenocarcinoma. RESULTS:...

journal_title：Pathology

authors： Yano T,Kishimoto T,Tomaru U,Kawarada Y,Kato H,Yoshiki T,Ishikura H

更新日期：2003-02-01 00:00:00

abstract：:Semen analysis is the most important laboratory investigation for men when assessing the infertile couple. Advances in in vitro fertilisation (IVF) techniques, particularly intracytoplasmic sperm injection (ICSI) involving the direct injection of a single spermatozoon into an egg, have not diminished the role of semen...

journal_title：Pathology

authors： McLachlan RI,Baker HW,Clarke GN,Harrison KL,Matson PL,Holden CA,de Kretser DM,Andrology Australia Australian Centre of Excellence in Male Reproductive Health.,Fertility Society of Australia Scientists in Reproductive Technology Subcommit

更新日期：2003-02-01 00:00:00

abstract：AIMS:In hereditary colorectal cancer (CRC) disorders such as familial adenomatous polyposis and hereditary non-polyposis colon cancer, the identification of germline mutations greatly assists in the clinical management of families. In addition, study of somatic mutations in the cancers themselves (both hereditary and s...

journal_title：Pathology

authors： Young J,Barker M,Fraser L,Walsh MD,Spring K,Biden KG,Hopper JL,Leggett BA,Jass JR

更新日期：2002-12-01 00:00:00

abstract：AIMS:Hep Par 1 has been described as a specific marker of hepatocellular differentiation and its immunohistochemical use has been suggested as a helpful tool for hepatocellular carcinoma (HCC) diagnosis. Most metastatic liver tumours come from the gastrointestinal tract and usually can be distinguished from HCC only th...

journal_title：Pathology

authors： Villari D,Caruso R,Grosso M,Vitarelli E,Righi M,Barresi G

更新日期：2002-10-01 00:00:00

abstract：AIMS:Malakoplakia is a characteristic inflammatory condition which is usually seen in the urogenital tract. Gastrointestinal malakoplakia is seen in association with a variety of conditions such as ulcerative colitis, diverticular disease, adenomatous polyps and carcinoma. The purpose of this paper is to report four ad...

journal_title：Pathology

authors： Pillay K,Chetty R

更新日期：2002-08-01 00:00:00

abstract：AIM:To determine whether the common respiratory pathogen, Chlamydia pneumoniae, was associated with atherosclerotic plaques in Australian subjects. METHODS:A total of 29 coronary atherosclerotic lesions and 18 normal coronary arterial samples were tested for the presence of C. pneumoniae by PCR and immunofluorescence ...

journal_title：Pathology

authors： Cochrane M,Kalle WH,Roffey P,Moriarty HT

更新日期：2002-06-01 00:00:00

abstract：:Human papillomavirus (HPV) is a common viral infection of squamous epithelial tissues, but its importance has only recently been recognised by the medical community. HPVs are now realised to consist of many genotypes and are associated with a diverse spectrum of clinical manifestations. Within the genital tract, some ...

journal_title：Pathology

authors： Garland SM

更新日期：2002-06-01 00:00:00

abstract：AIM:It is routine practice to prolong the incubation period of blood cultures from patients with suspected subacute bacterial endocarditis (SBE) or fungal infection. The protocol in this laboratory required 28 days incubation with weekly subcultures. Following the introduction of automated continuously monitored blood ...

journal_title：Pathology

authors： Varettas K,Taylor PC,Mukerjee C

更新日期：2002-04-01 00:00:00

abstract：:Gene targeting ('knock-out') technology is now widely used in the basic science of all disciplines of pathology and particularly auto-immune and inflammatory disease. Gene targeting is the wilful introduction of precise mutations into the genome of an animal, usually a mouse, affecting the function of a single gene or...

journal_title：Pathology

authors： Riminton DS

更新日期：2002-04-01 00:00:00

abstract：:Recent controversies both in Australia and overseas have focused public attention on autopsy practice. It has become apparent that there is an increasing expectation amongst the public for more detailed information concerning autopsy procedures and, in particular, tissue retention. This article attempts to review the ...

journal_title：Pathology

authors： Lynch MJ

更新日期：2002-02-01 00:00:00

abstract：:The aims of this study were to assess the value of specimen radiographs of stereotactic core biopsy, the usefulness of measuring size of calcifications on tissue sections, whether demonstration of calcifications in tissue sections alters the pathological diagnosis when specimen radiograph demonstrates calcifications, ...

journal_title：Pathology

authors： Dahlstrom JE,Jain S

更新日期：2001-11-01 00:00:00

abstract：:A total of 1434 strains of Neisseria meningitidis isolated from cases of invasive meningococcal disease (IMD) in Australia between 1994 and 1999 were examined by standard methods for susceptibility to antibiotics used for treatment and prophylaxis. The proportion of isolates fully susceptible to penicillin decreased f...

journal_title：Pathology

authors： Tapsall JW,Shultz T,Limnios E,Munro R,Mercer J,Porritt R,Griffith J,Hogg G,Lum G,Lawrence A,Hansman D,Collignon P,Southwell P,Ott K,Gardam M,Richardson CJ,Bates J,Murphy D,Smith H,National Neisseria Network of Austr

更新日期：2001-08-01 00:00:00

abstract：:We present the clinical and postmortem findings in seven adults (four females and three males), who died with dissection of the coronary arteries. The median age was 56 years. Five of the coronary artery dissections (CADs) were spontaneous and two followed trauma: one a motor vehicle accident, the other occurred durin...

journal_title：Pathology

authors： Mulvany NJ,Ranson DL,Pilbeam MC

更新日期：2001-08-01 00:00:00

abstract：:The in vitro activity of cefepime was compared to that of a range of other broad-spectrum agents, using a gradient diffusion MIC method, against 995 recent clinical isolates of Enterobacteriaceae, Pseudomonas aeruginosa, other nonfermentative gram-negative bacilli, staphylococci (except oxacillin-resistant Staphylococ...

journal_title：Pathology

authors： Bell JM,Turnidge JD,Cefepime Study Group.

更新日期：2001-02-01 00:00:00

abstract：:A male iniencephalic foetus of about 25 weeks gestation is described. The baby was born to a 22-year-old mother, who presented with abdominal pain of 1 day duration. An ultrasound scan at that time showed multiple foetal anomalies and the pregnancy was terminated. A stillborn baby was delivered. At autopsy, characteri...

journal_title：Pathology

authors： Loo CK,Freeman B,Stanford D

更新日期：2001-02-01 00:00:00

abstract：:The early and late effects of wound healing on tumour development at a distant site were evaluated morphologically in an experimental model of colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH). Random bred male Wistar rats were given subcutaneous injections of DMH (20 mg/kg) or saline, once a week, for eight...

journal_title：Pathology

authors： Sequeira JL,Kobayasi SS,Rodrigues MA

更新日期：2000-11-01 00:00:00

abstract：:The coexistence of a pancreatic papillary cystic tumor with hairy cell leukemia is reported. To the best of our knowledge this association has never been published. A 41-year-old man diagnosed with hairy cell leukemia developed a second malignancy that corresponded to a papillary cystic pancreatic tumor. The patient u...

journal_title：Pathology

authors： Acebo E,Rodilla IG,Torío B,Hernando M,García de Polavieja M,Morales D,Seco I,Bermudez A

更新日期：2000-08-01 00:00:00

abstract：:Apoptosis in the myocardium is complex and often difficult to recognise. Myocyte apoptosis is scattered across the myocardial wall and is restricted to individual cells. In the present study, we describe the amount of apoptosis in 50 endomyocardial biopsies taken from 50 patients with dilated cardiomyopathy, in 14 hea...

journal_title：Pathology

authors： Kavantzas NG,Lazaris AC,Agapitos EV,Nanas J,Davaris PS

更新日期：2000-08-01 00:00:00

abstract：:A rare case of extraskeletal osteosarcoma of the scalp in a 56-year-old woman is described. At presentation she was found to have an 8-cm diameter, tender, firm, exophytic scalp tumor. MRI scan confirmed absence of underlying skeletal origin and showed extension along the subcutaneous plane. The tumor was excised and ...

journal_title：Pathology

authors： Pillay P,Simango S,Govender D

更新日期：2000-05-01 00:00:00

abstract：:The most significant task of the pathologist examining a fetal death is, if possible, the provision of an explanation for the event, which will allow the clinical attendants to counsel the family in an informed and relevant manner. In some cases, no adequate explanation will be possible, though many conditions will be...

journal_title：Pathology

authors： Smith NM

更新日期：2000-05-01 00:00:00

abstract：:Lymphadenopathy associated with hemorrhage as a presenting feature of primary (AL) amyloidosis has not previously been described. We report two such cases one of whom had an acquired factor X and IX deficiency. The clinical presentations were characterized by sudden spontaneous enlargement of lymph nodes followed by p...

journal_title：Pathology

authors： Hanley JP,MacLean FR,Evans JL,Colls BM,Robinson BA,Patton WN,Heaton DC

更新日期：2000-02-01 00:00:00